GABA and Neuropsychiatric Disorders

GABA and neuropsychiatric disorders.

Because GABA appears to be an important, if not the primary, inhibitory neurotransmitter in brain, it is not surprising to find biochemical, physiological and behavioral data indicating that activation of the GABAergic system may be efficacious in the treatment of epilepsy (Meldrum, 1975). In addition, a significant loss of GABA neurons has been noted around the seizure foci in monkey cortex af...

Gut Microbiota and Neuropsychiatric Disorders

Bilingualism and neuropsychiatric disorders

A range of psychotic manifestations (including auditory hallucinations, delusions, conceptual disorganization, anxiety, and depression) have been reported to occur in either one or all of a patient’s languages. The reasons why one of the patient’s languages may be more affected than others is investigated. Whether a particular language should be used in psychotherapy, and if so, which one, is a...

Reelin and Neuropsychiatric Disorders

Proper neuronal migration and laminar formation during corticogenesis is essential for normal brain function. Disruption of these developmental processes is thought to be involved in the pathogenesis of some neuropsychiatric conditions. Especially, Reelin, a glycoprotein mainly secreted by the Cajal-Retzius cells and a subpopulation of GABAergic interneurons, has been shown to play a critical r...

[Homocysteine and neuropsychiatric disorders].

The author presents an overview of the current literature on homocysteine as a risk factor for neuropsychiatric disorders. The databases MEDLINE, Current Contents and EMBASE were searched (between 1966 and 2002) for English language publications with the key words 'Homocysteine' and 'Stroke'; 'Alzheimer Disease'; 'Cognitive Impairment'; 'Epilepsy'; 'Depression'; or 'Parkinson's disease'. Indivi...